Can we stop antibiotic resistance from ruining promising drugs before they reach patients?

What if we could predict early in drug development which antibiotics bacteria are most likely to become resistant to? In a review published in Nature Reviews Microbiology, researchers from the HUN-REN Biological Research Centre, Szeged (HUN-REN BRC Szeged) and the Hungarian Centre of Excellence for Molecular Medicine (HCEMM) in Szeged propose a five-step decision-making framework that could help identify resistance risks early, refine promising drug candidates and prevent costly failures.