Chemists harness light to build 3D molecular structures for drug discovery

Researchers from the Department of Chemistry at The University of Hong Kong (HKU), led by Professor Jian He and collaborators, have developed a new light-driven method for constructing three-dimensional molecular building blocks that could give medicinal chemists greater flexibility in designing new drug candidates. The approach broadens the range of starting materials that can be used while suppressing unwanted polymerization, overcoming key limitations of existing synthetic methods. The findings have been published in Nature Chemistry.