Bioinspired nanoparticles deliver gene editing to lower 'bad' cholesterol

Researchers from the Yong Loo Lin School of Medicine, National University of Singapore (NUS Medicine), and Tianjin Medical University General Hospital have developed a bioinspired lipid nanoparticle (LNP) that can deliver gene-editing machinery to the liver and reduce low-density lipoprotein (LDL) cholesterol, commonly known as "bad" cholesterol. The nanoparticles reduced LDL and total cholesterol by more than 20% after two doses, while showing fewer signs of inflammation and toxicity than comparator formulations. The findings were published in the Journal of Controlled Release.