Migrating charges unlock hard-to-reach C-H bond edits in organic molecules

A team at the University of Vienna, led by chemist Nuno Maulide, has developed a new method for controlling chemical reactions in a more targeted and efficient manner. At the heart of this is the concept of "cation sampling": specially selected groups (ketones), in a sense, function as molecular signposts for randomly migrating positive charges, enabling reactions to take place at sites on a molecule that were previously difficult to access. The method allows carbon-hydrogen bonds (C–H bonds) to be specifically modified. The study was published in the Journal of the American Chemical Society.