Metagenomics and AI could unlock uncultivated bacteria and archaea

Advances in DNA sequencing have expanded our view of the microbial world, but the inability to cultivate most microbes has been a major constraint. Now, a systematic, predictive framework that combines existing genomic and computational modeling approaches to accelerate the discovery and cultivation of novel prokaryotic taxa has been proposed by KAUST researchers, in collaboration with an international team of scientists. The work is published in The ISME Journal.