Researchers clarify how cells remove damaged endoplasmic reticulum
The cell's endoplasmic reticulum (ER) plays a central role in protein synthesis, folding, and calcium (Ca²⁺) storage. When damaged, ER-phagy (self-eating) removes affected ER regions via double-membrane vesicles called autophagosomes. However, the mechanisms underlying its initiation, signaling, and...
Image: Phys.org
The cell's endoplasmic reticulum (ER) plays a central role in protein synthesis, folding, and calcium (Ca²⁺) storage. When damaged, ER-phagy (self-eating) removes affected ER regions via double-membrane vesicles called autophagosomes. However, the mechanisms underlying its initiation, signaling, and membrane origin had previously been unclear.
Originally published at Phys.org
