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Nicotine's last biosynthesis steps mapped in wild tobacco, ending a long mystery
- April 10, 2026 at 11:20 PM
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Nicotine, a potent insecticidal alkaloid unique to the nightshade family, has been employed in agriculture as a pesticide since 1690. It also has therapeutic potential for neurological disorders such as Alzheimer's disease, Parkinson's disease, and depression. Despite its profound influence on human history, agriculture, and plant evolution, however, the final steps of nicotine biosynthesis have remained unclear until now.
Originally published at Phys.org