Nickel catalyst enables precision mirror-image assembly for key drug scaffolds

A research team led by Prof. Sangwon Seo of the Department of Physics and Chemistry at DGIST has developed a catalytic technology that can easily and elaborately assemble key structural frameworks that serve as the scaffold of bioactive compounds. Using an abundantly available and inexpensive nickel (Ni) catalyst, the team has successfully synthesized β-methylene carbonyl derivatives, which form the core framework of many pharmaceuticals, exclusively in a single mirror-image isomer form.