Antioxidant glutathione discovered to play a key role in proper protein folding

In the past several years, Rockefeller University's Kivanç Birsoy and his team in the Laboratory of Metabolic Regulation and Genetics have revealed remarkable details about the antioxidant glutathione, which plays many essential roles in the body, from clearing free radicals to repairing cellular damage. Among other things, they've discovered the transporter that shuttles glutathione to where it's needed, how glutathione keeps iron levels in check, and the metabolite's complicated relationship with mitochondria, the energy center of the cell, where it both keeps the lights on yet can drive the metastasis of breast cancer.