The key to attacking 'undruggable' proteins: Transient clustering state reveals a moving target
Intrinsically disordered proteins lack a fixed structure, which is why they have been considered "undruggable" targets for drug development for years. However, these proteins play a key role in numerous diseases—ranging from various types of cancer to neurodegenerative disorders—long limiting the th...
Image: Phys.org
Intrinsically disordered proteins lack a fixed structure, which is why they have been considered "undruggable" targets for drug development for years. However, these proteins play a key role in numerous diseases—ranging from various types of cancer to neurodegenerative disorders—long limiting the therapeutic options available to treat them.
Originally published at Phys.org
