Scientists engineer a 'Trojan Horse' to conquer aggressive brain cancer

Scientists from National Taiwan University (NTU) and Linkou Chang Gung Memorial Hospital (CGMH) have developed a precision-engineered nanoplatform to conquer glioblastoma (GBM), the most aggressive and deadly form of brain cancer. Treating glioblastoma is notoriously difficult due to its diffuse infiltration, the formidable blood-brain barrier (BBB), and a highly complex tumor microenvironment. A major component of this protective microenvironment are cancer-associated fibroblasts (CAFs)—stromal "helper" cells that support tumor growth and suppress the immune system.