Metal-free method unlocks selective carborane editing for cancer therapy and sensors

Carboranes are molecules composed of carbon, boron and hydrogen atoms that are proving to have applications of great interest in chemistry, materials science and biomedicine. They are being used, for example, in the fight against cancer through boron neutron capture therapy (BNCT), an experimental form of radiotherapy against malignant tumors that is highly selective at the cellular level. These compounds, which are highly stable at high temperatures and under radiation, possess unique electronic properties and can interact with various biochemical molecules. However, chemically modifying them to expand their potential properties and applications remains a challenge.